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MLK2 Kinase Enzyme System
PROV4476
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Recombinant human MLK2 (1-446) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag. MLK2 or mixed-lineage kinase 2 is a member of the serine/threonine kinase family, which activates MAPK8/JNK1 and MKK4/SEK1. MLK2 itself can be phoshorylated and activated by JNK kinases. MLK2 is also known as mitogen-activated protein kinase kinase kinase 10 (MAP3K10). MLK2 functions preferentially on the JNK signaling pathway, which is involved in nerve growth factor (NGF)-induced neuronal apoptosis. MLK2 was isolated as a cDNA fragment from MKN28 gastric cancer cell library using degenerate PCR (1). MLK2 is highly expressed in brain, skeletal muscle and testis (2). Kinase Enzyme System contains: Kinase: MLK2, 10ug (Human, recombinant; amino acids 1-446). MW: ~76kDa. Substrate: Native Swine Myelin Basic Protein (MBP). Other: Reaction Buffer, DTT. MLK2 NCBI Database Entry: www.ncbi.nlm.nih.gov/gene/4294/.

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