Carousel pipette stand for up to 6 mechanical pipettes, except bravo
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Recombinant human MLK1 (1-433) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag. MLK1 or Mixed-Lineage Kinase 1 is a mitogen-activated protein kinase kinase kinase capable of activating the c-Jun NH(2)-terminal kinase (JNK) pathway. The catalytic domain of MLK1 has amino acid sequence similarity to both the tyr-specific and the ser/thr-specific kinase classes. In addition, MLK1 contains 2 leu/ile-zipper motifs and a basic sequence near its C-termini (1). MLK1 is threonine (and possibly serine) phosphorylated at multiple sites in the activation loop, with phosphorylation of threonine 312 required for full activation (2). Kinase Enzyme System contains: Kinase: MLK1, 10ug (Human, recombinant; amino acids 1-433). MW: ~77kDa. Substrate: Native Swine Myelin Basic Protein (MBP). Other: Reaction Buffer, DTT. MLK1 NCBI Database Entry: www.ncbi.nlm.nih.gov/gene/4293/.
