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Full-length rhIRAK4 was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag. Interleukin-1 receptor-associated kinase 4 (IRAK4) is an important mediator in the signal transduction of Toll-like receptor (TLR) and IL1R family members. IRAK4 is involved in the Toll-like receptor signaling pathway leading to Apoptosis. IRAK4 has molecular functions like protein binding, ATP binding, kinase activity and magnesium ion binding. Toll/IL-1 receptor family members like IRAK4 are central components of host defense mechanisms in a variety of species. One well conserved element in their signal transduction is the Ser/Thr kinase activity, which couple early signaling events in a receptor complex at the plasma membrane to larger signalosomes in the cytosol. System contains: Kinase: IRAK4, 10ug (Human, recombinant full-length). MW: ~81kDa. Substrate: Native Swine Myelin Basic Protein (MBP). Other: Reaction Buffer, DTT. IRAK4 NCBI Database Entry: www.ncbi.nlm.nih.gov/gene/51135/.
