Southern Scientific Radhound Multi-purpose Digital Radiation Meter
Freephone: 0800 257 428 Email: sales@alphatech.co.nz
Full-length rhIKK alpha was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag. IKK alpha is a serine/threonine protein kinase that phosphorylates the I-kappa-B protein, which is an inhibitor of the transcription factor NF-kappa-B complex. Phosphorylation of I-kappa-B protein triggers the degradation of the inhibitor via the ubiquitination pathway, thereby activating NF-kappa-B complex (1). IKK alpha is an essential regulator of NF-kappa-B-dependent gene expression through control of promoter-associated histone phosphorylation after cytokine exposure (2). IKK alpha is a critical component of the cytoplasmic transductional-transcriptional processor leading to induction of IFN alpha production. System contains: Kinase: IKK alpha, 10ug (Human, recombinant full-length). MW: ~114kDa. Substrate: IKKtide (KKKKERLLDDRHDSGLDSMKDEE); derived from human IkBA (amino acids 21-41). Other: Reaction Buffer, DTT. IKK alpha NCBI Database Entry: www.ncbi.nlm.nih.gov/gene/1147/.
