Stuart Recirculating Coolers - SRC4, SRC14
Freephone: 0800 257 428 Email: sales@alphatech.co.nz
Full-length recombinant human FYN A was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag. FYN A (Fyn isoform A) is a member of the SRC tyrosine kinase oncogene family showing high homology to YES1, FGR and SRC. FYN has been shown to phosphorylate DAB1, an intracellular adaptor protein that interacts with amyloid precursor protein (APP) and apoE receptor 2 (apoEr2). The interaction of FYN and DAB1 regulates the phosphorylation, trafficking and processing of APP and apoEr2. FYN expression has been shown to be significantly increased in Chronic Myelogenous Leukemia (CML). Knockdown of FYN with shRNA slows leukemia cell growth, inhibits clonogenicity and leads to increased sensitivity to imatinib. Kinase Enzyme System contains: Kinase: FYN A, 10ug (Human, recombinant full-length). MW: ~85kDa. Substrate: Poly (4:1 Glu, Tyr) Peptide. Other: Reaction Buffer, DTT. FYN A NCBI Database Entry: www.ncbi.nlm.nih.gov/gene/2534/.
