CyBio Drop automated liquid handler
Freephone: 0800 257 428 Email: sales@alphatech.co.nz
Current methods for assessing the activity of SIRPalpha/CD47 checkpoint inhibitors rely on primary monocyte-derived macrophages and direct measurement of phagocytosis. These assays are laborious and highly variable due to their reliance on donor cells, complex assay protocols and unqualified assay reagents. As a result, these assays are difficult to establish in a quality-controlled setting. The SIRPalpha/CD47 Blockade Bioassay is a bioluminescent reporter cell-based assay used to measure the potency and stability of Fc-silent or Fc-null ligands and antibodies that bind and block SIRPalpha and CD47 interactions. For Fc-functional inhibitors, we recommend using the SIRPalpha/CD47 Blockade Bioassay, Fc-Dependent (Cat.# JA4802).
