Stuart Recirculating Coolers - SRC4, SRC14
Freephone: 0800 257 428 Email: sales@alphatech.co.nz
Recombinant full-length human SRC was expressed in E. coli cells using an N-terminal GST tag. SRC family belongs to nonreceptor tyrosine kinases. SRC was originally identified as a transforming protein of the Rous sarcoma virus (RSV) that had enzymatic ability to phosphorylate tyrosine in protein substrates. SRC is overexpressed and activated in a large number of human malignancies and has been linked to the development of cancer and progression to distant metastases. In addition to increasing cell proliferation, a key role of SRC in cancer seems to be the ability to promote invasion and motility, functions that might contribute to tumor progression. Kinase Enzyme System contains: Kinase: SRC, 10ug (Human, recombinant full-length). MW: ~83kDa. Substrate: SRC substrate (KVEKIGEGTYGVVYK-amide); derived from human p34cdc2 (amino acids 6-20). Other: Reaction Buffer, DTT, MnCl2. SRC NCBI Database Entry: www.ncbi.nlm.nih.gov/gene/6714/.
