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ADP-Glo(TM) Kinase Assay + RET (Y791F) Kinase Enzyme System
PROV5327
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Recombinant human RET (Y791F) (amino acids 658-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag. RET gene codes for a transmembrane tyrosine kinase, a subunit of a multimeric complex that acts as a receptor for 4 structurally related molecules: GDNF, neurturin, artemin and persephin. Germline mutations of RET cause a dominantly inherited dysgenesis of the enteric nervous system known as Hirschsprung's disease. RET is constitutively activated by point mutations in hereditary medullary thyroid carcinomas. Several single nucleotide polymorphisms of the RET gene have been described. Multiple endocrine neoplasia type 2A have been reported to be associated with two mutations of the proto-oncogene RET. Kinase: RET (Y791F), 10ug (Human, recombinant; amino acids 658-end). MW: ~74kDa. Substrate: IGF1Rtide (KKKSPGEYVNIEFG); derived from human IRS-1 protein residues 891-902. Reaction Buffer: DTT. RET (Y791F) NCBI Database Entry: www.ncbi.nlm.nih.gov/gene/5979/.

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