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ADP-Glo(TM) Kinase Assay + RET (V804L) Kinase Enzyme System
PROV4473
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Recombinant human RET (V804L) (amino acids 658-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag. RET gene codes for a transmembrane tyrosine kinase, a subunit of a multimeric complex that acts as a receptor for 4 structurally related molecules: GDNF, neurturin, artemin and persephin. Germline mutations of RET cause a dominantly inherited dysgenesis of the enteric nervous system known as Hirschsprung's disease. RET is constitutively activated by point mutations in hereditary medullary thyroid carcinomas. Several single-nucleotide polymorphisms of the RET gene have been described. Multiple endocrine neoplasia type 2A have been reported to be associated with two mutations of the proto-oncogene RET. Kinase: RET (V804L), 10ug (Human, recombinant; amino acids 658-end). MW: ~74kDa. Substrate: IGF1Rtide (KKKSPGEYVNIEFG); derived from human IRS-1 protein residues 891-902. Reaction Buffer: DTT. RET (V804L) NCBI Database Entry: www.ncbi.nlm.nih.gov/gene/5979/.

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