Bio-Nobile 96-M Robotic Workstation
Freephone: 0800 257 428 Email: sales@alphatech.co.nz
Recombinant human c-MER (amino acids 578-872) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag. c-MER is a tyrosine kinase and a member of the MER/AXL/TYRO3 receptor kinase family. The c-MER gene encodes a transmembrane protein with two fibronectin type-III domains, two Ig-like C2-type domains and one tyrosine kinase domain. Functional knockout of c-MER in mice shows the mice to have macrophages deficient in the clearance of apoptotic thymocytes thereby demonstrating the critical role for c-MER in the engulfment and efficient clearance of apoptotic cells. Defects in c-MER have been associated with retinitis pigmentosa, a phenotype that can be reversed by replacement of the c-MER gene product. Kinase Enzyme System contains: Kinase: c-MER, 10ug (Human, recombinant; amino acids 578-872). MW: ~58kDa. Substrate: Poly (4:1 Glu, Tyr) Peptide. Other: Reaction Buffer, DTT, MnCl2. c-MER NCBI Database Entry: www.ncbi.nlm.nih.gov/gene/10461/.
