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  1. Promega
  2. Cellular & Proteomic Solutions
  3. Cell Analysis

ADP-Glo(TM) Assay + SRPK1 Kinase Enzyme System
PROVA7560
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Recombinant full-length human SRPK1 was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag. SRPK1 is a Ser/Thr protein kinase that has sequence and function similar to SRPK2. In human cancer cells, it was observed that inactivation of SRPK1 induces cellular resistance to anticancer drugs such as cisplatin and bleomycin. SRPK1 phosphorylates serine/arginine-rich (SR) proteins, such as splicing factors ASF/SF2, SC35, and SRp55, in their arginine/serine-rich (RS) domains in vitro. Kinase Enzyme System contains: SRPK1 Kinase, 10ug (Human, recombinant, full-length); MW: ~130kDa. Native Swine Myelin Basic Protein (MBP) Substrate, (1mg/ml). 5X Reaction Buffer; DTT, 0.1M.

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