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TRKA Kinase Enzyme System
PROV2931
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Recombinant human TRKA (amino acids 440-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag. TRKA is a member of the trk proto-oncogene family and encodes a 140kDa membrane-spanning protein tyrosine kinase that is the functional receptor for nerve growth factor (NGF). NGF elicits the rapid phosphorylation of gp140trk on tyrosine residues leading to increased c-Fos expression, DNA synthesis and morphologic transformation. A decreased expression of TRKA on the striatal cholinergic neurons has been observed, which may contribute, when it reaches a crucial threshold, to the death of cholinergic neurons observed in Alzheimer disease. Kinase Enzyme System contains: Kinase: TRKA, 10ug (Human, recombinant; amino acids 440-end). MW: ~66kDa. Substrate: Poly (4:1 Glu, Tyr) Peptide. Other: Reaction Buffer, DTT. TRKA NCBI Database Entry: www.ncbi.nlm.nih.gov/gene/4914/.

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