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TRKA (G667C) Kinase Enzyme System
PROVA7339
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Recombinant human TRKA (G667C) (amino acids 440-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag. TRKA is a member of the trk proto-oncogene family and encodes a 140kDa, membrane-spanning protein tyrosine kinase that is the functional receptor for nerve growth factor (NGF). NGF elicits the rapid phosphorylation of gp140trk on tyrosine residues leading to increased c-Fos expression, DNA synthesis and morphologic transformation. A decreased expression of TRKA on the striatal cholinergic neurons has been observed which may contribute, when it reaches a crucial threshold, to the death of cholinergic neurons observed in Alzheimer disease. Kinase Enzyme System contains: TRKA (G667C) Kinase, 10ug (Human, recombinant; amino acids 440-end). MW: ~66kDa. Poly (4:1 Glu, Tyr) Substrate (1mg/ml). 5X Reaction Buffer, 2.5M MnCl2, 0.1M DTT.

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