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TGFbetaR1 Kinase Enzyme System
PROV6566
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Recombinant human TGF beta R1 (ALK5) (80-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag. TGF beta R1 or transforming growth factor beta-receptor 1 is a member of the TGF beta receptor subfamily and is a ser/thr protein kinase that forms a heteromeric complex with type II TGF-beta receptors when bound to TGF-beta, transducing the TGF beta signal from the cell surface to the cytoplasm. Mutations in the TGF beta R1 gene have been associated with Marfan syndrome, Loeys-Deitz Aortic Aneurysm Syndrome and the development of various types of tumors(1). TGF beta R1-dependent signaling is required for angiogenesis but not for the development of hematopoietic progenitor cells and functional hematopoiesis(2). Contains: TGF beta R1, 10ug (Human, recombinant; amino acids 80-end). MW: ~66kDa. Substrate: TGFBR1 Peptide (KKKVLTQMGSPSIRC-S(pS)VS); derived from human SMAD3 (215-230). Reaction Buffer, DTT. TGF beta R1 NCBI Database Entry: www.ncbi.nlm.nih.gov/gene/7046/

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