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TAK1-TAB1 Kinase Enzyme System
PROV6564
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Recombinant human proteins TAK1 (1-303) and TAB1 (437-end), linked by a small peptide (DFGGGGG), were expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag. TAK1 is a serine/threonine protein kinase that mediates signaling by TGF beta and morphogenetic protein. In response to IL-1, TAK1 forms a kinase complex with TAB1, required for activation of NF-KB. TAK1 also can activate MAPK8/JNK and MAP2K4/MKK4 to play a role in the cell response to environmental stress. TAK1 is essential for thymocyte development and activation; deletion of TAK1 prevents maturation of single-positive thymocytes displaying CD4 or CD8. Thymocytes lacking TAK1 fail to activate NF-KB and JNK and are prone to apoptosis upon stimulation. Kinase: TAK1-TAB1, 10ug (rh TAK1 (1-303) and TAB1 (437-end)). MW: ~74kDa. Substrate: Native Swine Myelin Basic Protein (MBP). Reaction Buffer, DTT. TAK1 NCBI Database Entry: www.ncbi.nlm.nih.gov/gene/6885/. TAB1 NCBI Database Entry: www.ncbi.nlm.nih.gov/gene/10454/

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