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RET (R912P) Kinase Enzyme System
PROVA7283
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Recombinant human RET (R912P) (658-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag. RET or ret proto-oncogene is a member of the cadherin superfamily that encodes one of the receptor tyrosine kinases, which are cell-surface molecules that transduce signals for cell growth and differentiation. RET can undergo oncogenic activation in vivo and in vitro by cytogenetic rearrangement. Mutations in the RET gene are associated with the disorders multiple endocrine neoplasia, type IIA, multiple endocrine neoplasia, type IIB, Hirschsprung disease, and medullary thyroid carcinoma. Kinase Enzyme System contains: RET (R912P) Kinase, 10ug (Human, recombinant; amino acids 658-end); MW: ~74kDa. IGF1Rtide Substrate (1mg/ml, KKKSPGEYVNIEFG); derived from human IRS-1 protein residues 891-902. 5X Reaction Buffer; DTT, 0.1M.

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