Human Corp Water Purification System
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Recombinant full-length human PIM2 was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag. PIM2 is a serine threonine kinase that is present in all tissues, being most abundant in hematopoietic tissues, spleen, thymus and peripheral blood leukocytes, as well as in testis, small intestine and colon (1). It is highly expressed in human leukemic, lymphoma and colorectal adenocarcinoma cell lines. This suggests a role for PIM2 in proliferating cells as well as during meiosis. Similar to PIM1, PIM2 also acts as a pro-survival kinase, and BAD protein is a legitimate PIM2 substrate (2). Kinase Enzyme System contains: Kinase: PIM2, 10ug (Human, recombinant full-length). MW: ~61kDa. Substrate: S6K Substrate (KRRRLASLR); derived from human 40S ribosomal protein S6 (amino acids 230-238). Other: Reaction Buffer, DTT. PIM2 NCBI Database Entry: www.ncbi.nlm.nih.gov/gene/11040/.
