Bioneer AccuRapid Cell-Free Protein Expression Kit
Freephone: 0800 257 428 Email: sales@alphatech.co.nz
Recombinant human PDGFR? (Y674I) (550-end) point mutant was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag. PDGFR? (platelet-derived growth factor receptor ?) is a member of the PDGFR family of membrane receptors with intrinsic tyrosine kinase activity. Aberrant expression of PDGFR? has been linked to developmental abnormalities in vertebrate models and implicated in multiple disease states in humans. There is widespread expression of PDGFR? in renal cell types involved in fibrotic and sclerosing processes. PDGF and its receptor PDGFR? are inducers of fibrosis in the repair phase of inflammatory bowel disease, and they may also be involved in the active inflammatory phase. Kinase Enzyme System contains: Kinase: PDGFR? (D842V), 10microg (Human, recombinant; amino acids 550-end). MW: ~95kDa. Substrate: Native Swine Myelin Basic Protein (MBP). Other: Reaction Buffer, MnCl2, DTT. PDGFR? (T674I) NCBI Database Entry: www.ncbi.nlm.nih.gov/gene/5156/.
