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Recombinant human PDGFR beta (amino acids 557-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag. PDGFR beta (platelet-derived growth factor receptor beta) is a member of the PDGFR family of membrane receptors with intrinsic tyrosine kinase activity. PDGFR beta-deficient mice are hemorrhagic, severely anemic and exhibit a defect in kidney glomeruli function. However, absence of PDGFR beta has no impact on major blood vessels and the heart. PDGFR beta expression and activity is elevated in several cancers, and inhibition of PDGFR beta activity blocks progression of renal carcinoma in an animal model. Kinase Enzyme System contains: Kinase: PDGFR beta, 10ug (Human, recombinant; amino acids 557-end). MW: ~104kDa. Substrate: Poly (4:1 Glu, Tyr) Peptide. Other: Reaction Buffer, DTT. PDGFR beta NCBI Database Entry: www.ncbi.nlm.nih.gov/gene/5159/.
