Specials

The NanoBRET Target Engagement (TE) Assay measures compound binding at select target proteins within intact cells. This target engagement assay is based on the NanoBRET System, an energy transfer technique designed to measure molecular proximity in living cells. The NanoBRET Target Engagement Assay analyzes the apparent affinity of test compounds by competitive displacement of a NanoBRET tracer reversibly bound to a NanoLuc fusion protein in a cell. We have a number of TE assays already developed for a large number of protein targets from a variety of protein classes. If there is no existing NanoBRET TE Assay for your target of interest, use the NanoBRET 590 Dyes to develop novel tracers to enable NanoBRET TE assays for new targets.