Human Corp Water Purification System
Freephone: 0800 257 428 Email: sales@alphatech.co.nz
Recombinant human MELK (1-340) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag. MELK or maternal embryonic leucine zipper kinase is a member of the Snf1/AMPK kinase family. MELK is a key regulator of the proliferation of malignant brain tumors including their stem cells (1). MELK transcript abundance correlates with malignancy grade in human astrocytomas and represents a therapeutic target for the management of the most frequent brain tumors in adult and children. MELK also plays a role in mammary carcinogenesis through inhibition of the pro-apoptotic function of Bcl-GL (2). Therefore, the kinase activity of MELK could be a promising molecular target for development of therapy for patients with breast cancers. Kinase Enzyme System contains: Kinase: MELK, 10ug (Human, recombinant; amino acids 1-340). MW: ~61kDa. Substrate: ZIPtide (KKLNRTLSFAEPG). Other: Reaction Buffer, DTT. MELK NCBI Database Entry: www.ncbi.nlm.nih.gov/gene/9833/.
