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MEKK3 Kinase Enzyme System
PROVA7498
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Recombinant full-length human MEKK3 was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag. MEKK3 is a member of the MEKK family of protein kinases that directly regulate SAPK and ERK pathway but not the p38 pathway. MEKK3 modulates SAPK and ERK activity by activating the upstream targets SEK and MEK1/2, respectively. KSR2 can regulate the activity of MEKK3 and can reduce MEKK3-mediated ERK activation. Kinase Enzyme System contains: MEKK3 Kinase, 10ug (Human, full-length recombinant). MW: ~105kDa. Native Swine Myelin Basic Protein (MBP) Substrate, (1mg/ml). 5X Reaction Buffer, 0.1M DTT.

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