Human Corp Water Purification System
Freephone: 0800 257 428 Email: sales@alphatech.co.nz
Recombinant human KDR (amino acids 789-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag. KDR (or kinase insert domain receptor) is a growth factor receptor tyrosine kinase originally isolated from human endothelial cells where it plays a pivotal role in endothelial cell proliferation and differentiation. KDR and its mouse homolog Flk1 bind VEGF with high affinity and are implicated in the development of new blood vessels (angiogenesis). VEGF and KDR expression levels are highly correlated during normal development of the ocular vasculature in humans. Induction of angiogenesis is a critical step in tumor progression, and inhibitors of KDR have been demonstrated both to induce tumor regression and reduce metastatic potential in preclinical models. System contains: Kinase: KDR, 10ug (Human, recombinant; amino acids 789-end). MW: ~110kDa. Substrate: Poly (4:1 Glu, Tyr) Peptide. Reaction Buffer, DTT. KDR NCBI Database Entry: www.ncbi.nlm.nih.gov/gene/3791/.
