Carousel pipette stand for up to 6 mechanical pipettes, except bravo
Freephone: 0800 257 428 Email: sales@alphatech.co.nz
Recombinant full-length human JNK1 (sequence matches mouse 100% in protein sequence) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag. JNK1 is a member of the MAP kinase group that is activated by dual phosphorylation at the thr and tyr residues during exposure to stress such as UV irradiation. JNK1 binds to the c-Jun transactivation domain and phosphorylates it on Ser-63 and Ser-73 (1). JNK1 has been shown to play an important role in disease processes. Activation of JNK1 results in defects in myotube viability and integrity leading to dystrophic myofiber destruction (2). JNK1 activity also is abnormally elevated in obesity, and removal of JNK1 results in decreased adiposity and significantly improved insulin sensitivity. Kinase Enzyme System contains: Kinase: JNK1, 10ug (Human, recombinant full-length). MW: ~70kDa. Substrate: p38 substrate (IPTTPITTTYFFFKKK). Other: Reaction Buffer, DTT. JNK1 NCBI Database Entry: www.ncbi.nlm.nih.gov/gene/26419/.
