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HGK Kinase Enzyme System
PROVA7471
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Recombinant human HGK (amino acids 1-328) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag. HGK is the mitogen-activated protein kinase kinase kinase kinase 4 (MAP4K4) and a member of the serine/threonine protein kinase family. HGK has been shown to specifically activate MAPK8/JNK. The activation of MAPK8 by HGK can be inhibited by dominant-negative mutants of MAP3K7/TAK1, MAP2K4/MKK4, and MAP2K7/MKK7, which suggest that this kinase functions through the MAP3K7-MAP2K4-MAP2K7 kinase cascade and mediates TNF-alpha signaling. Kinase Enzyme System contains: HGK Kinase, 10ug (Human, recombinant; amino acids 1-328). MW: ~64kDa. Native Swine Myelin Basic Protein (MBP) Substrate (1mg/ml). 5X Reaction Buffer, 0.1M DTT.

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