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The GloResponse Luciferase Reporter Cell Lines contain optimized, state-of-the-art luciferase reporter technology integrated into a cell line to achieve rapid development of a reporter assay based on the pathway of interest regulating the luciferase gene. Assays configured using these cell lines are amenable for high-throughput screening. These assays typically have greater response dynamics (fold of induction) than other assay formats and are of good quality as indicated by high Z' values. GPCRs regulate a wide-range of biological functions and are one of the most important target classes for drug discovery. GPCR signaling pathways can be categorized into three classes based on the G protein alpha-subunit involved: Gs, Gi/o and Gq. The GloResponse CRE-luc2P HEK293 Cell Line can be used to study and configure screening assays for Gs- and Gi/o-coupled GPCRs, which signal through cAMP and the cAMP Response Element (CRE).
