Carousel pipette stand for up to 6 mechanical pipettes, except bravo
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Recombinant human FLT3 (571-993) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag. FLT3 is a receptor tyrosine kinase that has been shown to play a role in proliferation and survival of hematopoietic progenitor cells as well as differentiation of early B lymphoid progenitors (1). FLT3 consists of an extracellular domain composed of five immunoglobulin-like domains, one transmembrane region and a cytoplasmic kinase domain split into two parts by a kinase-insert domain. FLT3 is the most frequently mutated gene in cases of acute myelogenous leukemia (AML). About 30% to 35% of patients have either internal tandem duplications (ITDs) in the juxtamembrane domain or mutations in the activating loop of FLT3 (2). Kinase Enzyme System contains: Kinase: FLT3, 10ug (Human, recombinant; amino acids 571-993). MW: ~73kDa. Substrate: Native Swine Myelin Basic Protein (MBP). Other: Reaction Buffer, DTT. FLT3 NCBI Database Entry: www.ncbi.nlm.nih.gov/gene/2322/.
