CyBio Drop automated liquid handler
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Full-length rhFES was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag. FES is a proto-oncogene that encodes a protein-tyrosine kinase distinct from c-Src, c-Abl and other nonreceptor tyrosine kinases. FES was originally identified as the cellular homolog of several transforming retroviral oncoproteins. FES plays a role in regulating cytoskeletal rearrangements and inside-out signaling that accompany receptor ligand, cell matrix and cell-cell interaction. Genetic analysis using a transgenic mouse model implicates FES in the regulation of inflammation and innate immunity. FES modulates the innate immune response of macrophages to LPS challenge, in part, by regulating the internalization and downregulation of the TLR4 receptor complex. System contains: Kinase: FES, 10ug (Human, recombinant full-length). MW: ~125kDa. Substrate: Poly (4:1 Glu, Tyr) Peptide. Other: Reaction Buffer, DTT, MnCl2. FES NCBI Database Entry: www.ncbi.nlm.nih.gov/gene/2242/.
