Freephone: 0800 257 428 Email: sales@alphatech.co.nz
Recombinant full-length human DYRK1B was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag. DYRK1B (Dual specificity tyrosine-phosphorylation-regulated kinase 1B) is a member of the evolutionarily conserved DYRK family with key roles in the control of cell proliferation and differentiation. DYRK1B acts in G0/G1 to maintain cells in growth arrest and quiescence by targeting cyclin D1 for proteasomal degradation by phosphorylating a threonine residue close to the C terminus. Kinase Enzyme System contains: DYRK1B Kinase, 10ug (Human, recombinant full-length). MW: ~106kDa. DYRKtide Substrate (RRRFRPASPLRGPPK) (1mg/ml). 5X Reaction Buffer, 0.1M DTT.
