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Recombinant human DDR2 (467-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag. DDR2 is a member of a novel subclass of RTKs containing a distinct extracellular region encompassing a factor VIII-like domain (1) and is thought to be involved in the regulation of cell growth, differentiation and metabolism. DDR2 plays a role in the regulation of collagen turnover mediated by smooth muscle cells in obstructive diseases of blood vessels and the lung (2). Kinase Enzyme System contains: Kinase: DDR2, 10ug (Human, recombinant; amino acids 467-end). MW: ~70kDa. Substrate: Axltide (CKKSRGDYMTMQIG); derived from mouse insulin receptor substrate 1 (amino acids 979-989). Other: Reaction Buffer, DTT, MnCl2. DDR2 NCBI Database Entry: www.ncbi.nlm.nih.gov/gene/4921/.
