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CDK5/p25 Kinase Enzyme System
PROV3232
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Full-length rhCDK5 and p25 were co-expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag on both proteins. CDK5 is a member of the Cyclin-Dependent Kinase family that is most abundant in the mammalian brain. The active form of CDK5, also called neuronal cdc2-like kinase, is a heterodimer of CDK5 and a 25kDa protein, which is derived proteolytically from a 35kDa brain and neuron-specific protein and is essential for the kinase activity of CDK5. CDK5 has emerged as a crucial regulator of neuronal migration in the developing central nervous system. CDK5 phosphorylates a diverse list of substrates, implicating it in the regulation of a range of cellular processes---from adhesion and motility to synaptic plasticity and drug addiction. Kinase Enzyme System contains: Kinase: CDK5/p25, 10g (Human, recombinant full-length). MW: (CDK5) ~59kDa; (p25) ~49kDa. Substrate: Histone H1 protein. Other: Reaction Buffer, DTT. CDK5/p25 NCBI Database Entry: www.ncbi.nlm.nih.gov/gene/1020/

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