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rhCAMK2 gamma (C-terminal truncation) was expressed by baculovirus in Sf9 cells using an N-terminal GST tag. A member of the CAMKII family, CAMK2 gamma has 6 alternatively spliced variants that encode 6 different isoforms. Some of these variants have been identified in human tumors. Transgenic mice expressing a partially calcium-independent mutant form of CAMKG showed 1.5- to 2-fold increase in the thymus of these mice, at least in part due to an increase in the life span of double-positive thymocytes. There was an increase in the number of T cells in the secondary lymphoid organs that had acquired an antigen-dependent memory phenotype. Kinase Enzyme System contains: Kinase: CAMK2 gamma, 10ug (Human, recombinant; C-terminal truncation). MW: ~60kDa. Substrate: Autocamtide-2 (KKALRRQETVDAL-amide); derived from the autophosphorylation site (amino acid 283-290) on CaMKII. Other: Reaction Buffer, DTT, Ca2+/Calmodulin solution. CAMK2 gamma NCBI Database Entry: www.ncbi.nlm.nih.gov/gene/818/.
