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BCR-RET Kinase Enzyme System
PROVA7030
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Recombinant human BCR-RET, the fusion protein [BCR (1-426)-RET (713-end)], was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag. BCR-RET is a chimeric fusion of BCR and RET genes generated by a balanced translocation of genes from t(10;22)(q11;q11) and this leads to aberrant activation of RET activity which can transform hematopoietic cells and skew the hematopoietic differentiation program towards the monocytic/macrophage lineage. Kinase Enzyme System contains: BCR-RET Kinase, 10microg [Human, recombinant; amino acids 1-426 (BCR), 713-end (RET)]. MW: ~140kDa. IGF1Rtide Substrate (1mg/ml), (KKKSPGEYVNIEFG), derived from human IRS-1 protein residues 891-902. 5X Reaction Buffer, 0.1M DTT.

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