Carousel pipette stand for up to 6 mechanical pipettes, except bravo
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Full-length rhAurora B was expressed by baculovirus in Sf9 cells using an N-terminal GST tag. Aurora B is a member of the Aurora kinase family that associates with microtubules during chromosome movement and segregation. Aurora B localizes to the microtubules near kinetochores, specifically to the specialized microtubules called K-fibers. Aurora B inhibits the microtubule depolymerizing activity of mitotic centromere-associated kinesin (MCAK) by phosphorylating MCAK on Ser92. This phosphorylation also regulates MCAK translocalization from kinetochores to the centromere. Aurora B has been identified as a target for the development of new anticancer agents since inhibition of Aurora B gives rise to the more pronounced antiproliferative phenotype. Kinase Enzyme System contains: Kinase: Aurora B, 10ug (Human, recombinant full-length). MW: ~68kDa. Substrate: Native Swine Myelin Basic Protein (MBP). Other: Reaction Buffer, DTT. Aurora B NCBI Database Entry: www.ncbi.nlm.nih.gov/gene/9212/.
