Human Corp Water Purification System
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Recombinant full-length human Aurora A was expressed by baculovirus in Sf9 cells using an N-terminal GST tag. Aurora A belongs to a multigenic family of mitotic serine/threonine kinases, which are involved in the control of chromosome segregation. Aurora A is involved in centrosome separation, duplication and maturation as well as in bipolar spindle assembly and stability. Aurora A is expressed and active at the highest level during G2-M phase of the cell cycle. Overexpression of Aurora A has been found to be correlated with the grade of various human solid tumors. Ectopic Aurora A overexpression in any culture cell line leads to polyploidy and centrosome amplification. Kinase Enzyme System contains: Kinase: Aurora A, 10ug (Human, recombinant full-length). MW: ~72kDa. Substrate: Native Swine Myelin Basic Protein (MBP). Other: Reaction Buffer, DTT. Aurora A NCBI Database Entry: www.ncbi.nlm.nih.gov/gene/6790/.
