Pestle, 0.5ml, Assorted, 400/Case
Freephone: 0800 257 428 Email: sales@alphatech.co.nz
Recombinant human ALK2 (147-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag. ALK2 is a receptor serine/threonine kinase that is member of the ALK family and is upstream of signaling pathway involving the SMAD proteins, especially SMAD1/5/8. Knockdown of ALK2, but not TGFbetaRI (ALK5), abrogates endoglin-mediated decrease in cell motility of prostate cancer cells, and constitutively active ALK2 is sufficient to restore a low-motility phenotype in endoglin-deficient cells (1). Therefore, endoglin decreases prostate cancer cell motility through activation of the ALK2-Smad1 pathway. ALK2 is the key gene involved in Fibrodysplasia ossificans progressiva (2). Kinase Enzyme System contains: Kinase: ALK2, 10ug (Human, recombinant; amino acids 147-end). MW: ~67kDa. Substrate: Native Casein Protein; purified from bovine milk. Other: Reaction Buffer, DTT. ALK2 NCBI Database Entry: www.ncbi.nlm.nih.gov/gene/90/.
