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  1. Promega
  2. Cellular & Proteomic Solutions
  3. Cell Analysis

ADP-Glo(TM) Kinase Assay + TBK1 Kinase Enzyme System
PROV8291
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Recombinant full-length human TBK1 was expressed by baculovirus in Sf9 cells using an N-terminal GST tag. TBK1, also known as NAK or NFkB-activating kinase, is an upstream protein kinase that can phosphorylate and activate the IkB kinases. Activation of IkB kinases allows the phosphorylation of IkB protein, which is then degraded via the ubiquitination pathway. This mechanism allows the activation of the NFkB transcriptional complex. TBK1 is a specific upstream regulator of IkB kinases and also can interact with the IkB protein TANK. TBK1 is a component of the virus-activated kinase that phosphorylate IRF3 and IRF7, allowing their dimerization and translocation to the nucleus, where they induce transcription of interferon. Kinase Enzyme System contains: Kinase: TBK1, 10ug (Human, recombinant full-length). MW: ~105kDa. Substrate: Native Swine Myelin Basic Protein (MBP). Other: Reaction Buffer, DTT. TBK1 NCBI Database Entry: www.ncbi.nlm.nih.gov/gene/29110/.

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