Southern Scientific Radhound Multi-purpose Digital Radiation Meter
Freephone: 0800 257 428 Email: sales@alphatech.co.nz
Recombinant human PDGFR alpha (D842V) (550-end) point mutant was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag. PDGFR alpha (platelet-derived growth factor receptor alpha) is a member of the PDGFR family of membrane receptors with intrinsic tyrosine kinase activity. Aberrant expression of PDGFR alpha has been linked to developmental abnormalities in vertebrate models and implicated in multiple disease states in humans. There is widespread expression of PDGFR alpha in renal cell types involved in fibrotic and sclerosing processes (1). PDGF and PDGFR alpha are inducers of fibrosis in the repair phase of inflammatory bowel disease, and they may also be involved in the active inflammatory phase (2). System contains: Kinase: PDGFR alpha (D842V), 10ug (Human, recombinant; amino acids 550-end). MW: ~95kDa. Substrate: Native Swine Myelin Basic Protein (MBP). Reaction Buffer: DTT, MnCl2. PDGFR alpha (D842V) NCBI Database Entry: www.ncbi.nlm.nih.gov/gene/5156/.
