Applied Separations Solid Phase Extraction (SPE)
Freephone: 0800 257 428 Email: sales@alphatech.co.nz
Recombinant full-length mouse PAK3 was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag. PAK3 is a member of the family of serine/threonine p21-activating kinases that serve as targets for the small GTP-binding proteins Cdc42 and RAC (1). The PAK family of proteins has been implicated in a wide range of biological activities and its critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling. PAK3 seems to be necessary for dendritic development and for the rapid cytoskeletal reorganization in dendritic spines associated with synaptic plasticity. A point mutation in the PAK3 gene has been linked to nonsyndromic X-linked mental retardation (2). Kinase Enzyme System contains: Kinase: PAK3, 10ug (Mouse, recombinant full-length). MW: ~89kDa. Substrate: Native Swine Myelin Basic Protein (MBP). Other: Reaction Buffer, DTT. PAK3 NCBI Database Entry: www.ncbi.nlm.nih.gov/gene/18481/.
