CyBio Drop automated liquid handler
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Recombinant human JAK3 (amino acids 781-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag. JAK3 is a member of the JAK family of tyrosine kinases involved in cytokine receptor-mediated intracellular signal transduction. Low levels of JAK3 expression is detected in immature hematopoietic cells, which dramatically increases during terminal differentiation of these cells, suggesting a role of JAK3 in the differentiation of hematopoietic cells. Mutations in JAK3 are associated with autosomal SCID (severe combined immunodeficiency disease). Mice lacking JAK3 show a severe block in B-cell development at the pre-B stage in bone marrow, suggesting that JAK3 is critical for the progression of B-cell development in the bone marrow. Kinase Enzyme System contains: Kinase: JAK3, 10ug (Human, recombinant; amino acids 781-end). MW: ~64kDa. Substrate: Poly (4:1 Glu, Tyr) Peptide. Other: Reaction Buffer, DTT. JAK3 NCBI Database Entry: www.ncbi.nlm.nih.gov/gene/3718/.
