Bioneer ExiProgen Protein Biosynthesis, DNA/RNA Purification Instrument
Freephone: 0800 257 428 Email: sales@alphatech.co.nz
Recombinant full-length human GRK5 was expressed by baculovirus in Sf9 cells using an N-terminal GST tag. GRK5 is a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. It phosphorylates the activated forms of G protein-coupled receptors thus initiating their deactivation. GRK5 plays a role in regulating the motility of polymorphonuclear leukocytes (PMNs). Desensitization of G protein-coupled receptors regulates the number of polymorphonuclear leukocytes (PMNs), as well as their motility and ability to stop pathogens or target cells upon contact, and this desensitization is mediated by GRK5. Kinase Enzyme System contains: Kinase: GRK5, 10ug (Human, recombinant full-length). MW: ~95kDa. Substrate: Native casein protein purified from bovine milk. Other: Reaction Buffer, DTT. GRK5 NCBI Database Entry: www.ncbi.nlm.nih.gov/gene/2869/.
