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Recombinant human FMS (539-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag. FMS is a proto-oncogene that encodes the tyrosine kinase transmembrane receptor for colony stimulating factor 1 receptor (CSF1R). FMS is homodimeric, contains a so-called kinase insert domain and is a member of the CSF1R/PDGF receptor family of tyrosine-protein kinases. FMS mediates most if not all of the biological effects of CSF1, which control the production, differentiation and cell function the monocyte/macrophage lineage (1). Mutations in FMS have been associated with providing sustained signals for cell growth and a predisposition to myeloid malignancy (2). Kinase Enzyme System contains: Kinase: FMS, 10ug (Human, recombinant; amino acids 539-end). MW: ~76kDa. Substrate: Poly (4:1 Glu, Tyr) peptide. Other: Reaction Buffer, DTT, MnCl2. FMS NCBI Database Entry: www.ncbi.nlm.nih.gov/gene/1436/.
