Human Corp Water Purification System
Freephone: 0800 257 428 Email: sales@alphatech.co.nz
Recombinant human ALK6 (BMPR1B) (149-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag. ALK6 (also known as BMPR1B) is a member of the transmembrane serine/threonine kinase that is the member of the bone morphogenetic protein (BMP) receptor, which is closely related to the activin receptors, ACVR1 and ACVR2. ALK6 is mainly involved in the endochondral bone formation and embryogenesis. ALK6 is expressed in normal and cancerous prostate tissues and used in the endocrine therapy given to prostate cancer patients (1). ALK6 receptor trafficking also plays a significant role in FOP pathogenesis and is used in human T-cell differentiation (2). Kinase Enzyme System contains: Kinase: ALK6, 10ug (Human, recombinant; amino acids 149-end). MW: ~68kDa. Substrate: TGFBR1 peptide (KKKVLTQMGSPSIRCS(pS)VS); derived from human SMAD3 (215-230). Other: Reaction Buffer, DTT. ALK6 NCBI Database Entry: www.ncbi.nlm.nih.gov/gene/658/.
