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  1. Promega
  2. Cellular & Proteomic Solutions
  3. Cell Analysis

ADP-Glo(TM) Assay + FLT3 (ITD-NPOS) Kinase Enzyme System
PROVA7170
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Recombinant human FLT3 (ITD-NPOS) (571-993) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag. Fms-related tyrosine kinase 3 (FLT3) is a gene that encodes for a tyrosine kinase that activates pathways in hematopoietic cells important in cellular proliferation. FLT3 is frequently mutated in acute myeloid leukemia (AML), myelodysplastic syndromes, other hematologic malignancies, and colorectal cancer. FLT3 mutations are observed in 24.3% of AML, of which internal tandem duplications (ITD) are the most frequent. FLT3 ITD occurs when sequences of less than ten to several hundred bases in length are repeated within the juxtamembrane domain are always ?in-frame?. Kinase Enzyme System contains: FLT3 (ITD-NPOS) Kinase, 10ug (Human, recombinant; amino acids 571-993). MW: ~82kDa. Native Swine Myelin Basic Protein (MBP) Substrate, (1mg/ml). 5X Reaction Buffer, 0.1M DTT.

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