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Current methods for measuring ADCP rely on the isolation of primary human monocytes, ex vivo differentiation into macrophages and direct measurement of phagocytosis. These assays are laborious and highly variable due to their reliance on donor cells, complex assay protocols and unqualified assay reagents. As a result, these assays are difficult to establish in quality-controlled, drug development settings. The ADCP Reporter Bioassay (THP-1) is a bioluminescent reporter cell-based assay used to measure the potency and stability of antibodies and other biologics with Fc domains that bind and activate FcgammaRs.
