
Fc receptor-mediated antibody-dependent cell-mediated cytotoxicity (ADCC) is an important mechanism of action (MOA) by which antibodies target disease cells for elimination.The ADCC Reporter Bioassays, F Variant, use NFAT-mediated luciferase activity in effector cells as indicator of ADCC MOA, providing an alternative to traditional primary cell-based assays for measuring the effect of biologics on ADCC activity.They are accurate, precise and stability-indicating and prequalified according to ICH guidelines, making them suitable for all stages of biologic research and development.